Status:
COMPLETED
GABA-glutamate Interactions and Psychosis
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Alliance for Research on Schizophrenia and Depression
Conditions:
Cognitive Dysfunction
Eligibility:
All Genders
21-45 years
Phase:
PHASE1
Brief Summary
This study investigates the interactions between NMDA (N-Methyl-D-aspartic acid) antagonism and GABA (gamma-aminobutyric acid) system as it relates to cognitive function assessed by ERPs (event-relate...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Ages of 21-45 years from all ethnic backgrounds.
- Male or female.
- Written informed consent.
- Exclusion criteria:
- DSM-IV diagnosis for a psychotic, depressive or anxiety disorder.
- A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox).
- History of abnormal EEG.
- History of severe allergies or multiple adverse drug reactions.
- Any medication that could interfere with either the safety of the study and/or the outcome measures.
- Any other conditions which in the opinion of the investigator would preclude participation in the study.
- History of major psychiatric disorder in first degree relatives.
- Current substance abuse/dependency determined by urine toxicology.
- Treatment with medications with CNS effects.
- Treatment with benzodiazepines within one week prior to testing.
- Current treatment with medications with psychotropic effects.
- Education \< 10th grade.
- IQ \< 70, MR.
- Non-English speaking.
Exclusion
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 2 2018
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT00611572
Start Date
January 1 2007
End Date
October 2 2018
Last Update
July 22 2022
Active Locations (1)
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1
VHA Connecticut
West Haven, Connecticut, United States, 06516