Status:
COMPLETED
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
Lead Sponsor:
Yale University
Collaborating Sponsors:
VA Connecticut Healthcare System
Conditions:
Alcoholism
Eligibility:
All Genders
21-30 years
Phase:
NA
Brief Summary
This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alterat...
Detailed Description
This project will explore the hypothesis that individuals with a family history positive for alcohol dependence (FHP) (without any current DSM-IV Axis I disorder, except nicotine dependence), experien...
Eligibility Criteria
Inclusion
- Male and female between the ages of 21 and 30 years
- medically and neurologically healthy on the basis of history, physical examination, Electrocardiogram (EKG), screening laboratories
- absence of any evidence of substance abuse (with the exception of nicotine dependence) on the basis of history and drug and ethanol-free at the time of testing based on urine toxicology and breath alcohol levels at screening and on each test day.
Exclusion
- Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) Axis I psychiatric and substance abuse or dependence diagnosis by history on psychiatric evaluation that includes a structured diagnostic interview (SCID)
- unwillingness to remain alcohol-free for three days prior to each test day;
- for women, positive pregnancy test at screening or intention to engage in unprotected sex during the study and
- alcohol naive. For Family History Positive Subjects: 1) Biological father and another first or second-degree biological relative with history of alcoholism by Family History Assessment Module (FHAM) developed by The Collaborative Study on the Genetics of Alcoholism (COGA).
- For Family History Negative Subjects: NO family history of alcoholism in any first or second-degree relatives. Subjects must reliably report on three first-degree relatives.
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT00611767
Start Date
November 1 2005
End Date
April 1 2012
Last Update
March 17 2017
Active Locations (1)
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1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516