Status:
COMPLETED
Effects of Atomoxetine Treatment in Humans
Lead Sponsor:
Yale University
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Stress
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
PHASE2
Brief Summary
A total of 18 healthy volunteers will participate in this four-week, within-groups, double-blind, placebo-controlled study. The study has two phases separated by a 4 to 15-day washout period. Subjects...
Detailed Description
Objective: This pilot study will examine the effects of a norepinephrine reuptake blocker, atomoxetine, on physiological and subjective responses to physical and psychological models of stress and ora...
Eligibility Criteria
Inclusion
- Female and males, age 18 to 45 years
- Current history of good health and normal ECG
- For women: not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods.
Exclusion
- History of heart disease, hypertension, renal or hepatic diseases, glaucoma, hyperthyroidism, or other medical conditions that the physician investigator deems as contraindicated for the patient to be in the study
- Current use of psychotropic medication(antidepressants, antipsychotics, or anxiolytics) and/or diagnosis and treatment for Axis I disorders including major depression, bipolar affective disorder, schizophrenia and panic disorder within the past year.
- Current dependence on alcohol or on drugs or treatment for drug or alcohol addiction(amphetamines have greater abuse liability among those with drug addictions) within the past 5 years.
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00611936
Start Date
June 1 2006
End Date
September 1 2009
Last Update
July 25 2012
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