Status:
TERMINATED
Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
Lead Sponsor:
University of California, Irvine
Conditions:
Normal Pressure Hydrocephalus
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The research project is designed to determine which combination of tests will enable physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH) will improve with a sh...
Detailed Description
Normal pressure hydrocephalus (NPH) is a potentially reversible progressive neurological condition disproportionately affecting the elderly population. Given current controversies regarding its exact ...
Eligibility Criteria
Inclusion
- Walking difficulties in both legs which has developed gradually, not explained by other conditions, either in combination with mental impairment and urinary incontinence
- Brain CT or MRI findings of enlarged ventricles compared to established standards (minimum Evans ratio of 0.30 as measured by reviewing films)
- Mental impairment must be mild to moderate, emerging with or after the walking difficulties
- Age \> or = 18 years old
- MMSE (Mini-mental status exam): \< or = 10
- Urinary incontinence
Exclusion
- No or only minimal walking difficulties combined with severe dementia
- Severe medical problems with limited life expectancy (less than six months)
- Contraindications to surgery
- Lack of informed consent
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00613886
Start Date
March 1 2006
End Date
April 1 2009
Last Update
January 12 2021
Active Locations (1)
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1
University of California, Irvine - Medical Center
Orange, California, United States, 92868