Status:
COMPLETED
Effect of Intravenous Nutrition and Epidural Analgesia on Protein Loss After Surgery
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Postoperative Protein Catabolism
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Loss of muscle mass and body protein are the main causes of fatigue after bowel surgery, which may result in a longer hospital stay and a higher rate of complications. This particularly applies to mal...
Detailed Description
The major objective of the nutritional management of surgical patients is to accelerate wound healing and increase resistance to infection while preventing wastage of functional and structural protein...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists \<3
- colorectal surgery for non-metastatic colorectal carcinoma including right and left hemicolectomy, transverse, subtotal and total colectomy, sigmoid resection
- ability to give informed consent
Exclusion
- signs of severe malnutrition or obesity: body mass index \<18 or \>25 \>10% involuntary body weight loss over the preceding 6 months serum albumin \<21 g/L
- significant cardiorespiratory, hepatic, renal and neurological disease
- ingestion of drugs known to affect protein, glucose and lipid metabolism (for example steroids)
- musculoskeletal or neuromuscular disease
- severe anemia (hemoglobin \<10 g/dL)
- pregnancy
- history of severe sciatica or back surgery or other conditions which contraindicate the use of epidural catheters
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00614133
Start Date
June 1 2004
End Date
June 1 2007
Last Update
February 13 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Royal Victoria Hospital, McGill University Health Centre
Montreal, Quebec, Canada, H3A 1A1