Status:
COMPLETED
Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage
Lead Sponsor:
Kuopio University Hospital
Collaborating Sponsors:
University of Eastern Finland
Conditions:
Subarachnoid Hemorrhage
Cerebral Aneurysm
Eligibility:
All Genders
18+ years
Brief Summary
Subarachnoid haemorrhage (SAH) may cause damage to the hypotalamo-pituitary-adrenal axis (HPA) thus disturbing the hormonal response of these structures. The aim of our study is to characterize the f...
Detailed Description
The hypotalamo-pituitary-adrenal (HPA)-axis may be affected in SAH by temporary or permanent damage to the hypothalamus and/or pituitary gland. Also surgery or endovascular treatment of a ruptured int...
Eligibility Criteria
Inclusion
- SAH-group:
- \>age 18,
- Subarachnoid hemorrhage due to an cerebral aneurysm
- Control group:
- Age \>18
- Admitted for elective primary cerebral aneurysm surgery
Exclusion
- SAH group:
- Any corticoid treatment (also inhaled)
- Usage of etomidate before study entry or during the study period
- Exact bleeding day unknown
- Previous history of SAH or more than three days of current bleeding
- Previous aneurysm surgery or embolization
- Traumatic SAH
- Known pituitary insufficiency and moribund state of the patient
- Refusement of the patient
- control group:
- Any corticoid treatment (also inhaled)
- Usage of etomidate before study entry or during the study period
- Previous history of SAH or cerebral aneurym surgery or embolization
- Admitted for elective aneurysm embolization
- Known pituitary insufficiency
- Refusement of the patienT
Key Trial Info
Start Date :
March 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00614887
Start Date
March 1 2006
End Date
January 1 2008
Last Update
October 26 2023
Active Locations (1)
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1
Department of Intensive Care, Kuopio University Hospital
Kuopio, PL 1777, Finland, 70211