Status:
COMPLETED
Treatment With Erythropoietin and Cognition During Hypoglycaemia
Lead Sponsor:
Hillerod Hospital, Denmark
Collaborating Sponsors:
Maastricht University Medical Center
Rigshospitalet, Denmark
Conditions:
Type 1 Diabetes
Hypoglycemia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of the trial is to determine if erythropoietin (EPO) can enhance cognitive function during hypoglycaemia in patients with type 1 diabetes. Patients with type 1 diabetes will receive one i...
Detailed Description
Experimental protocol 6 days before hypoglycemic clamp subjects attended the clinic, and information about demography, lifestyle and clinical characteristics was collected. A physical examination with...
Eligibility Criteria
Inclusion
- Type 1 diabetes
- Hypoglycaemia unawareness
- 2 or more episodes of hypoglycaemia in the last 12 months
- Age \>18 år
- Duration of diabetes \> 5 år
- Weight \> 50 kg
- No pregnancy
- Informed consent
Exclusion
- Pregnancy
- Heart failure (NYHA 2-4)
- Ischaemic heart disease
- Epilepsy
- Venous thromboembolic disease
- Thrombocytosis
- Beta receptor antagonists
- Disturbance of vision
- History of stroke
- History of erythropoietin treatment
- Plasma-creatinin \> 100 umol/l (male)or 88 umol/l (female)
- Plasma-haemoglobin \< 7,0 or \> 11 mmol/l at time of inclusion
- Operation with blood loss within the last 6 weeks
- Cancer
- Treated with ciclosporin
- Suspicion of non-compliance with protocol
- Conditions incompatible with participation - e.g. safety considerations.
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00615368
Start Date
May 1 2008
End Date
December 1 2010
Last Update
August 24 2015
Active Locations (1)
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1
Hillerød Hospital
Hillerød, Hillerød, Denmark, 3400