Status:
WITHDRAWN
A Pilot Evaluation of the Impact of Alcohol Use on Airway Inflammation and Mechanics in Asthmatics
Lead Sponsor:
Emory University
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Asthma
Eligibility:
All Genders
18-65 years
Brief Summary
Since 1980, the number of people in the United States diagnosed with asthma has increased dramatically. Studying what causes and triggers asthma is an important part of understanding and subsequently ...
Eligibility Criteria
Inclusion
- 18 to 65 years of age
- Literate in English (i.e., read study materials at 6th grade level) so as to understand, and complete the ratings scales and questionnaires accurately
- Physician-diagnosed asthma requiring treatment in the past year with a post bronchodilator FEV1/FVC \>0.70 and at least 12% reversibility after bronchodilator usage
- Alcohol usage groups: 1) those who rarely or who do not drink alcohol (≤2 drinks per month); or 2) those who drink 3 or more alcoholic beverages per day on average
Exclusion
- Social drinkers (\>2 drinks in a month but \<3 drinks per day)
- Asthma exacerbation within the past month
- Current upper respiratory infection
- Active allergies with uncontrolled symptoms
- Current DSM-IV diagnosis of illicit substance dependence (not alcohol)
- History of serious pulmonary problems other than asthma
- Other significant non-pulmonary comorbidities
- Pregnancy or currently lactating
- Daily use of Prednisone or other corticosteroids
- Tobacco smoking within the past year or \>10 life-time pack-years of smoking
- Positive breath alcohol level at the time of the study assessments
- Positive urine cotinine test at enrollment (indicates nicotine usage)
Key Trial Info
Start Date :
January 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00615407
Start Date
January 1 2007
Last Update
November 18 2013
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