Status:
COMPLETED
Effect of Continuous Positive Airway Pressure (CPAP) Treatment in the Control of Refractory Hypertension
Lead Sponsor:
Sociedad Española de Neumología y Cirugía Torácica
Conditions:
Sleep Apnea
Hypertension
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The working hypothesis for the present study is that treatment with CPAP in patients with an sleep apnea (IAH\>15) and AHT-r is capable of producing significant reductions in blood-pressure levels. T...
Detailed Description
OBJECTIVE. To evaluate the effect of continuous positive airway pressure (CPAP) treatment on the blood-pressure (BP) levels of patients with refractory arterial hypertension (AHT-r). METHODS: Multice...
Eligibility Criteria
Inclusion
- Patients aged 18-75 with a diagnosis of primary AHT-r and an AHI ≥15.
- Signature indicating informed consent.
Exclusion
- Those patients with, in the opinion of the researcher, incapacitating hypersomnia will be excluded (to avoid the ethical problems associated with not treating a symptomatic sleep apnea patient).
- Patients with risky professions or work involving dangerous goods.
- Pregnancy.
- The regular use of psychotropic drugs that could significantly modify the results of the sleep studies, or previous alcoholism (more than 100 gr of alcohol/day).
- Patients previously treated with CPAP.
- Record of poor compliance with anti-hypertensive treatment.
- AHT secondary to cardiac insufficiency, valvulopathy, renal or endocrinological causes, cor pulmonale or the consumption of oral corticoids, or any other known cause.
- Patients who have suffered from a cardiovascular event in the month prior to inclusion in the study, or patients who were unstable at the time of their inclusion in the study.
- Known renal insufficiency with a concentration of creatinine greater than 1.5 mg/dl
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2012
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT00616265
Start Date
June 1 2008
End Date
February 1 2012
Last Update
February 29 2012
Active Locations (1)
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1
General Hospital of Requena
Valencia, Valencia, Spain, 42340