Status:
COMPLETED
Does Sleep Quality Change After Switch From Wellbutrin SR to Wellbutrin XL in Patients With Major Depressive Disorder?
Lead Sponsor:
Queen's University
Conditions:
Mood Disorder
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
Wellbutrin (bupropion) is an effective antidepressant (Thase, M 2005). It exists in instant release (IR), sustained release (SR) and extended release (XL) forms. The IR formulation was never approved ...
Detailed Description
Wellbutrin SR formulation cannot be given as more than 150 mg as a single dose and higher doses are commonly required for the treatment of depression; they also have to be given at least 8 hours apart...
Eligibility Criteria
Inclusion
- Signed Patient Informed Consent;
- Patients with Major Depressive Disorders (DSM-IV-TR - criteria used);
- Out-patients;
- Males or females over 18 years of age;
- Patients currently using Wellbutrin SR.
Exclusion
- Bipolar Disorder patients;
- Actively suicidal patients;
- Schizophrenia, Schizoaffective or other Psychotic Disorder;
- Pregnant women, as by pregnancy test at the beginning of the study;
- Women in childbearing age, refusing to use appropriate contraception, or breastfeeding mothers;
- Patients with known hypersensitivity to bupropion;
- Patients with severe or unstable medical conditions, which in the opinion of the investigator would interfere with their progress or safety;
- ECT or TMS treatments within the last three months;
- Patients who did not respond to previous treatment with bupropion;
- Patients with history of seizure disorder;
- Patients with history of eating disorders (e.g. bulimia, anorexia nervosa);
- Patients using sleep aiding medication (Benzodiazepines, barbiturates).
Key Trial Info
Start Date :
January 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00616915
Start Date
January 1 2007
End Date
January 1 2010
Last Update
December 16 2015
Active Locations (1)
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1
Providence Care Mental Health Services
Kingston, Ontario, Canada, L7L 4X3