Status:
ACTIVE_NOT_RECRUITING
Effect of Pulmonary Rehabilitation on Surgical Outcomes in the Cancer Setting
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Lung Cancer
Eligibility:
All Genders
Phase:
PHASE2
Brief Summary
The goal of this clinical research study is to see if pulmonary rehabilitation can improve patients' lung function, which would increase their chances of becoming eligible for surgery. The health of p...
Detailed Description
Pulmonary rehabilitation is a process that is designed to improve patients' lung function, muscular conditioning, exercise performance, and overall quality of life. Study activities include exercise ...
Eligibility Criteria
Inclusion
- Patients with anatomically resectable lung tumors who are deemed surgically inoperable based on preoperative pulmonary function testing FEV1 \< 80% pred; DLCO \< 80% pred; FEV1ppo \< 40% pred; DLCO ppo \< 40% pred AND VO2 peak \< 60% predicted or \< 15 ml/kg/min.
- Patients deemed surgically inoperable based on poor performance status (ECOG score 2-3)
- Any non-pulmonary co-morbidity must be stable according to institutional guidelines.
Exclusion
- Previously reported severe pulmonary hypertension (pulmonary artery systolic pressure \> 60 as determined by echocardiogram), refractory cor pulmonale (as manifested by right ventricular dilatation or dysfunction by echocardiogram)
- Previously reported exercise-induced syncope, angina, palpitation, arrhythmia, hypotension (drop of 20% of systolic/diastolic from baseline)
- History of severe congestive heart failure (NYHA class 3 and 4) refractory to medical management, (LVEF \< 40% by echocardiogram).
- Bone metastasis
- Active psychiatric illness that could interfere with treatment.
Key Trial Info
Start Date :
January 28 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00618553
Start Date
January 28 2008
End Date
September 1 2025
Last Update
July 30 2025
Active Locations (1)
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1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030