Status:
COMPLETED
Study of Long-Term Antibiotic Treatment in Reactive Arthritis
Lead Sponsor:
University of Helsinki
Conditions:
Reactive Arthritis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a randomized, double-blind, placebo-controlled trial of the effect of 3-month treatment with the combination of 200 mg ofloxacin twice daily and 150 mg roxithromycin twice daily on clinical co...
Eligibility Criteria
Inclusion
- Diagnosis of acute reactive arthritis
- Preceding infection confirmed by positive culture and/or serology, or with a history of urethritis or gastroenteritis within the preceding 2 months
- Age 18 or older
Exclusion
- Allergy to quinolones or macrolides
- Treatment with systemic corticosteroids within 2 weeks
- Serum creatinine level elevated over the reference limit
- Alanine aminotransferase or alkaline phosphatase levels elevated over twice the reference limit
- Current or planned pregnancy, or lack of contraception
- Known HIV positivity
- Blood leukocyte count less than 4.0x109/l
- Blood platelet count less than 100x109/l
- Lack of co-operation.
Key Trial Info
Start Date :
November 1 1993
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 1998
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00621387
Start Date
November 1 1993
End Date
June 1 1998
Last Update
February 22 2008
Active Locations (2)
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1
Division of Rheumatology, Department of Medicine
Helsinki, Finland, 00029
2
Peijas Hospital
Vantaa, Finland, 01400