Status:
TERMINATED
Effect of Spinal Ketorolac on Mechanical Hypersensitivity After a Total Hip Replacement
Lead Sponsor:
Wake Forest University
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Hip Arthroplasty
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Chronic pain in patients following total hip replacement seems to be a significant problem. Previous research has shown that more effective pain management in the early postoperative period may decrea...
Detailed Description
Surgery results in hypersensitivity to mechanical stimuli surrounding the wound and in a subset of patients, also results in chronic pain. The purpose of the study is to test whether intrathecal ketor...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) physical status I, II, III
- \> Age 18
- Primary unilateral total hip arthroplasty under spinal anesthesia
Exclusion
- Known allergy to study medication
- Weight \> 300 pounds
- Obstructive sleep apnea
- Patients with severe renal (kidney) or hepatic (liver) disease, allergy to ketorolac, amino amide local anesthetic, or contraindications to spinal anesthesia
- Patients on dialysis for kidney failure or patients that are jaundice or have a diagnosis of liver failure
- Patients routinely taking narcotic pain medications for pain other than their primary hip pain
- Patients that are taking Lyrica (pregabalin) or Gabapentin (neurontin) for the treatment of seizures
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
62 Patients enrolled
Trial Details
Trial ID
NCT00621530
Start Date
March 1 2008
End Date
June 1 2013
Last Update
September 11 2018
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States, 27157
2
The Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44120