Status:
COMPLETED
Energy Expenditure & Activity During & After Exercise-Induced Weight Loss
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
This project is aimed at determining whether an exercise-based weight loss intervention causes a compensation in some component of energy expenditure such that the increase in measured energy expendit...
Detailed Description
The primary aim of this proposed study is to determine how total daily activity thermogenesis (TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans attempting to lose weight a...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Body mass index (BMI) 30-35.0 kg/m2
- Age 18-45 years
- Weight stable (\<2 kg weight fluctuation during previous 6 months)
- No regular exercise (\> 1 bout of exercise/wk or participation in any sporting activities \> 1 hr/wk)
- No self-report of acute or chronic disease (diabetes, heart diseases, and joint problems in particular)
- No current use of prescribed medications
- No plans to relocate within the next year
- No plans for extended travel (\> 1 week) within the next 6 months
- No tobacco use
- For Females:
- No evidence of amenorrhea (Regular menstrual cycles of 21-35 days)
- Pre-menopausal status (self-report, to be confirmed during screening)
- Pregnancy or lactating within the past year
- No pregnancy or planned pregnancies; sexually active women of childbearing potential may be enrolled if they have had a tubal ligation or use one of the following means of contraception: condom, diaphragm, oral or implanted contraceptives, or intrauterine device. Women in exclusive relationships with male partners who have had a successful vasectomy will not be required to use any additional means of birth control.
- Exclusion Criteria:
- Claustrphobia;
- Any contraindication(s) to \> MRI, e.g. aneurysm, cochlear implant, cardiac pacemaker, or implantable cardiac defibrillator, artificial heart valve, metallic stents, any implantable devices or shunt, weight less than 300 lbs;
- Left Handed.
Exclusion
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00622310
Start Date
September 1 2007
End Date
June 1 2008
Last Update
July 12 2021
Active Locations (1)
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1
University of Colorado, School of Medicine
Aurora, Colorado, United States, 80045