Status:
COMPLETED
A Prospective Study of Microalbuminuria in Untreated Boys With Alport Syndrome
Lead Sponsor:
University of Minnesota
Collaborating Sponsors:
University of Utah
Conditions:
Alport Syndrome
Kidney Disease
Eligibility:
MALE
Up to 18 years
Brief Summary
The goal of the Microalbuminuria in Untreated Boys with Alport Syndrome study is to gather information about critical clinical time points such as when patients with small amounts of protein (microalb...
Detailed Description
Study Aims 1. To determine the average ages of onset of microalbuminuria and overt proteinuria in untreated boys with Alport syndrome 2. To determine the average duration of microalbuminuria before t...
Eligibility Criteria
Inclusion
- Diagnosis of Alport syndrome, confirmed by skin biopsy, kidney biopsy, or molecular genetic analysis
- Diagnosis of Alport syndrome, based on presence of hematuria and confirmed diagnosis of Alport syndrome in a first-degree relative
- Male gender
- Absence of overt proteinuria, defined as urine protein:creatinine ratio less than 0.2 mg/mg
- Subject is not currently receiving treatment with an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB)
Exclusion
- Female gender
- Presence of overt proteinuria
- Current treatment with ACEI or ARB
- End-stage kidney disease (on dialysis or kidney transplant recipient)
Key Trial Info
Start Date :
July 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00622544
Start Date
July 1 2007
End Date
July 1 2012
Last Update
July 20 2018
Active Locations (1)
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1
University of Minnesota
Minneapolis, Minnesota, United States, 55455