Status:
COMPLETED
Carbohydrates and Related Biomarkers
Lead Sponsor:
Fred Hutchinson Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Healthy
Overweight
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
This study is designed to investigate associations of low- and high-glycemic load diets with biomarkers of hyperglycemia, hyperinsulinemia and inflammation, potential biomarkers for cancer risk.
Detailed Description
This is a randomized, crossover feeding study conducted in normal weight and overweight individuals. Participants will be given all their food to eat and drink (except water) for two 28-day feeding pe...
Eligibility Criteria
Inclusion
- Healthy males and female subjects
- Between the ages of 18 to 45
- BMI between 18.5 kg/m2 to 24. 9 kg/m2 (normal weight) and between 28.0 kg/m2 to 39.9 kg/m2 (overweight)
- Willingness to refrain from alcohol during the study
- Able to come to the FHCRC in Seattle every weekday night for dinner
Exclusion
- Younger than 18 years of age or older than 45 years of age.
- Do not fit into one of the study weight groups (normal weight and overweight): BMI \< 18.5 kg/m2 or \> 40.0 kg/m2, and between 25.0 kg/m2and 27.9 kg/m2
- Have diseases that are treated by diet and/or medications including but not limited to diabetes, kidney disease, heart disease
- Taking prescription medications every day (this includes women taking birth-control pills, shots, patch or IUD with hormones)
- Diagnosed with or treated for cancer within the previous five years (except those with a diagnosis and/or treatment of non-melanomatous skin cancer are eligible)
- Currently pregnant or breastfeeding or planning a pregnancy in the next 3 months.
- Using any tobacco products on a daily basis (cigarettes, pipes, cigars, chewing tobacco).
- Using recreational drugs
- Drinking the following amount of alcohol almost every day: 2 or more cans/bottles of beer OR 2 or more glasses of wine OR 3 or more ounces of hard liquor.
- Inability (e.g., food allergy or intolerances) or unwillingness to consume the foods that are part of the feeding study diet.
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT00622661
Start Date
June 1 2006
End Date
July 1 2010
Last Update
January 5 2012
Active Locations (1)
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1
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109