Status:
COMPLETED
Bioenergetic Alterations After Exenatide Administration
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to find out how exenatide causes weight loss. Specifically, the study is assessing how exenatide may change how people take in energy (energy intake), as well as how it ma...
Detailed Description
The bioenergetics study is looking at how and why the diabetes drug exenatide causes people to lose weight.Bioenergetics is the study of how your body burns calories. Adults 18-65 who do not have dia...
Eligibility Criteria
Inclusion
- 18-65 years of age
- BMI between 30 and 40 kg/m2
- Women with a negative pregnancy test at baseline, who are sterile, using contraceptives or in a committed relationship with someone who is sterile or using contraception
- Absence of weight change greater than 3 kg in the previous 6 months
Exclusion
- Women who are pregnant or lactating
- Current or recent (6 months) enrollment in a commercial or self prescribed weight loss or exercise program
- Use of weight loss medication
- A history of metabolic disease i.e. renal, endocrine, hepatic or gastrointestinal disease that would impact the outcome of the study
- Presence of medical conditions that are known to affect energy expenditure (i.e. hyperthyroidism, rheumatoid arthritis, AIDS among others)
- History of hypoglycemia
- A history of psychiatric or eating disorder
- Abnormal EKG
- Previous history of pancreatitis
- Previous history of gastroparesis or GI motility disorder
- Use of medications that can affect GI motility
- History of organ transplantation
- Other comorbid conditions which may preclude the subject's ability to complete the study
- Use of a carbonic anhydrase inhibitor such as acetazolamide
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00623545
Start Date
January 1 2008
End Date
April 1 2010
Last Update
January 9 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Univ Wisconsin Hospital and Clinics
Madison, Wisconsin, United States, 53792