Status:
COMPLETED
Ketamine Improves Post-Thoracotomy Analgesia
Lead Sponsor:
Tel-Aviv Sourasky Medical Center
Conditions:
Post Operative Pain
Eligibility:
All Genders
Phase:
NA
Brief Summary
Thoracotomy for lung tumor or for minimally invasive direct coronary artery bypass (MIDCAB) surgery, may be associated with debilitating pain. Ketamine was shown to enhance opioid antinociception and ...
Detailed Description
We planned a prospective, randomomized, double blind study of 2 pain management protocols in consecutive patients undergoing thoracotomy for MIDCAB or lung tumor resection over a 6 month period. After...
Eligibility Criteria
Inclusion
- Consecutive patients scheduled for elective minimally invasive direct coronary artery bypass (MIDCAB) or for lung resection via anterolateral thoracotomy during a 6-month period (Sep 2001-March 2002)
Exclusion
- Exclusion criteria were:
- American Society of Anesthesiologists (ASA) physical class ≥3, Emergency operations,
- Q-wave myocardial infarct occurring during the previous 3 weeks, or poor left ventricular function (e.g., ejection fraction \[EF\] \<30% by echocardiography or angiography).
- Other exclusion criteria were:
- A body mass index \>35 kg/m2,
- Past or current neuropathy or psychological disturbances,
- The use of centrally active drugs,
- Chronic liver or renal failure requiring dialysis,
- A FEV1/FVC \<70%,
- Allergy to ketamine, morphine or non steroidal anti inflammatory drugs (NSAIDs),
- Clotting abnormalities,
- A platelets count \<70000/mm3,
- A white blood count \<3000\>14000/mm3,
- Uncontrolled diabetes mellitus or fasting blood glucose \>250 g/dl,
- Evidence of sepsis or infection up to one week prior to randomization.
Key Trial Info
Start Date :
September 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2002
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00625911
Start Date
September 1 2001
End Date
March 1 2002
Last Update
February 29 2008
Active Locations (1)
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1
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel, 64238