Status:
COMPLETED
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
Lead Sponsor:
University of California, San Francisco
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
18+ years
Brief Summary
Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.
Detailed Description
To determine if a correlation exists between EPC function and eNOS-dependent NO production in EPCs from populations with high versus low cardiovascular risk: 1. High and low cardiovascular risk subje...
Eligibility Criteria
Inclusion
- Willing and able to give written informed consent and comply with study requirements
- Adult of 18 years or older
- Subjects willing to provide blood and tissue samples
Exclusion
- Failure to give informed consent.
- Those unable to consent for themselves.
- Those who cannot read English.
- Patients on Viagra, Levitra, or Cialis
- Patients with malignant disease
- Patients with hematological abnormalities
- Patients with fevers of unknown origin
- Severe comorbidity or alcohol/drug dependence
- Women who are post-menopausal and on hormone replacement therapy, or premenopausal and on birth control pills (premenopausal women will be screened verbally and then by assay of LH and FSH levels in blood samples to identify women in the follicular phase of their menstrual cycle, to reduce variability)
Key Trial Info
Start Date :
July 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00627068
Start Date
July 1 2007
End Date
December 1 2010
Last Update
September 20 2011
Active Locations (1)
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1
UCSF, Department of Cardiology
San Francisco, California, United States, 94143