Status:
COMPLETED
Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study)
Lead Sponsor:
Carelon Research
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Neutropenia
Infection
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
Neutropenia, a condition characterized by an abnormally low number of infection-fighting white blood cells called neutrophils, commonly develops in people who have undergone chemotherapy or hematopoie...
Detailed Description
Thousands of people each year are hospitalized for neutropenia, which continues to cause substantial morbidity and mortality for those affected. Neutropenia is primarily caused by chemotherapy and var...
Eligibility Criteria
Inclusion
- Severe neutropenia (Absolute Neutrophil Count \< 500/mm\^3) due to marrow failure caused by underlying disease or therapy
- Must have one of the following: fungemia; bacteremia; proven or presumptive invasive tissue bacterial infection; or proven, probable, or presumptive invasive fungal infection
Exclusion
- Unlikely to survive 5 days
- Evidence that patient will not be neutropenic at least 5 days
- Previously enrolled in this study
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT00627393
Start Date
April 1 2008
End Date
May 1 2013
Last Update
April 17 2015
Active Locations (13)
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1
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
2
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21267
3
Children's Hospital Boston
Boston, Massachusetts, United States, 02115
4
University of Minnesota
Minneapolis, Minnesota, United States, 55455