Status:
UNKNOWN
Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
University Hospital Birmingham
Collaborating Sponsors:
Heart of England NHS Trust
British Heart Foundation
Conditions:
Heart Failure, Diastolic
Eligibility:
All Genders
40-85 years
Brief Summary
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These pati...
Eligibility Criteria
Inclusion
- Clinical features consistent with heart failure
- LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction
- A peak VO2 \< 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation
Exclusion
- Objective evidence of lung disease on formal lung function testing
- Reversible myocardial ischaemia on contrast-enhanced myocardial stress
- Echocardiography, and evidence of exercise-induced mitral regurgitation
- Obesity (BMI \>35) or a locomotor cause for exercise limitation
Key Trial Info
Start Date :
March 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2009
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00628082
Start Date
March 1 2006
End Date
April 1 2009
Last Update
March 4 2008
Active Locations (1)
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1
University of Birmingham
Birmingham, United Kingdom, B15 2TT