Status:
COMPLETED
Investigating the Acute Effects of THC on Functional Brain Systems
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
Center for Human Drug Research
Leiden University Medical Center
Conditions:
Reward
Tetrahydrocannabinol
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
Detailed Description
Cannabis is by far the most frequently used illicit drug worldwide and has significant effects on memory. Further, cannabis has an addictive potential. These effects are mediated by an action of THC, ...
Eligibility Criteria
Inclusion
- History of mild cannabis use for at least one year (\<1/week and ≥ 4/year)
- History without psychotic experiences after cannabis use
- Age between 18 and 45 years
- Right-handedness, assessed with the Edinburgh Handedness Inventory
- Written informed consent of the subject
Exclusion
- Any clinical significant abnormality of any clinical laboratory test, including urinary drug screening
- Impaired physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests
- History of clinically significant psychiatric or neurological illness
- History of clinically significant psychiatric or neurological illness in first- or second-degree relatives
- History of alcohol and/or drug abuse (DSM-IV criteria)
- Body Mass Index (B.M.I.) \<18 kg/m2 or \>28 kg/m2
- Paranoid ideation or psychoticism on SCL-90
- Any subject who received any investigational medication within 90 days prior to the start of the study or who is scheduled to receive an investigational drug
- The use of any medication within three weeks prior to the start of the study, except for paracetamol
- Positive HIV or Hepatitis B/C test
- Blood donation within 3 months before the start of the study
- Claustrophobia
- Metal objects in or around the body (braces, pacemaker, metal fragments)
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2008
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00628706
Start Date
April 1 2008
End Date
September 1 2008
Last Update
February 18 2009
Active Locations (1)
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1
University Medical Center Utrecht
Utrecht, Netherlands, 3584CX