Status:
COMPLETED
The Role of Cerebral Hemodynamics in Moyamoya Disease
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Moyamoya
Stroke
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.
Detailed Description
Moyamoya disease is a rare medical disorder that affects the blood vessels (pipes that transport blood) in the brain. In Moyamoya disease, the large blood vessels in the middle of the brain close down...
Eligibility Criteria
Inclusion
- Adult \> 18 years of age
- Capable of informed consent
- Clinical: Both asymptomatic and symptomatic patients will be included.
- Anatomic: Unilateral or bilateral imaging findings consistent with moyamoya collaterals (Suzuki stages 3 and 4) on digital subtraction, computed tomographic, or magnetic resonance angiography (after Suzuki and Kodama, 1983)
Exclusion
- Any other disease that might be responsible for the vasculopathy, including atherosclerosis, neurofibromatosis, meningitis, sickle cell disease, skull base radiation therapy.
- Pregnancy: All women of child-bearing potential will be tested for pregnancy on the day of the enrollment and throughout the course of the study.
- Surgery: Prior open or endovascular revascularization procedures, unless there have been ischemic symptoms since surgery and angiographic evidence that the procedure was not successful
Key Trial Info
Start Date :
October 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00629915
Start Date
October 1 2006
End Date
June 1 2015
Last Update
May 7 2018
Active Locations (1)
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1
Washington University School Of Medicine, 510 South Kingshighway Blvd
St Louis, Missouri, United States, 63110