Status:
COMPLETED
DZX Mediated Insulin Suppression in Obese Men
Lead Sponsor:
Rijnstate Hospital
Conditions:
Obesity
Eligibility:
MALE
25-50 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether there is an additive effect of metformine on the weight reduction of obese hyperinsulinemic men who are treated with diazoxide.
Eligibility Criteria
Inclusion
- male
- age 25-50 years
- BMI 30-35 kg/m2
- stable body weight during 3 months before the start of the study
- glucose \<= 6.0 mmol/L
- C-peptide \>= 1.0 nmol/L
- HbA1c \<= 6.0%
Exclusion
- comorbidity
- medication
- serum creatinine \> 120 micromol/L
- liver enzymes \> 2 times upper limits of normal
- gout
- alcohol use \> 2 alcoholic drinks a day
- drug abuse
- cessation of smoking less than 6 months ago
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00631033
Start Date
July 1 2008
End Date
December 1 2011
Last Update
November 6 2014
Active Locations (1)
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1
Rijnstate Hospital
Arnhem, Netherlands