Status:
WITHDRAWN
Assessment of Hemodynamic Changes During Weaning From Mechanical Ventilation With Flo-Trac Vigileo (TM) Monitor.
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
Edwards Lifesciences
Conditions:
Mechanical Ventilation
Eligibility:
All Genders
18+ years
Brief Summary
Failure to wean from mechanical ventilation (failure to get the patients off the breathing machine) is associated with prolonged stay in the intensive care unit and increased risk of death. Some patie...
Detailed Description
In the process of liberation or discontinuation from mechanical ventilation (also commonly referred as "weaning") the goal is to achieve spontaneous breathing and ultimately extubation. Weaning failur...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Arterial line in place
- Normal sinus rhythm by electrocardiographic monitoring
- Mechanical ventilation for at least 24 hours
- Ventilation via oral or nasal endotracheal tube
- Patient meets the following weaning criteria before starting weaning protocol:
- PaO2/FiO2 ratio \>200
- FiO2 equal or less than 50%
- Positive end-expiratory pressure (PEEP) 5cm H20 or less
- Respiratory frequency/Tidal volume ratio less 105
- Respiratory rate \< 30 breaths/min
- Presence of cough and gag reflex
- 12 hours free from sedation (opioids/benzodiazepine)
- 2 hours free from sedation in case patient is on Propofol
- Systolic blood pressure above 90 mmHg and below 180 mmHg
- Heart rate below 130 beats/min
Exclusion
- Known neurological disorder that might impair ventilatory drive
- Known neuromuscular disease
- Inotropic or vasopressor infusion
- Cardiac pacemaker
- Terminal condition
Key Trial Info
Start Date :
February 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00631683
Start Date
February 1 2008
End Date
February 1 2008
Last Update
November 5 2020
Active Locations (1)
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1
Memorial Hermann Hospital
Houston, Texas, United States, 77030