Status:
UNKNOWN
SAPPHIRe III in Taiwan-Progression Evaluation and Cardiovascular Outcomes of Hypertensive Families
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborating Sponsors:
National Taiwan University Hospital
Tri-Service General Hospital
Conditions:
Hypertension
Eligibility:
All Genders
40-70 years
Brief Summary
The purpose of this study is to determine the progression evaluation, cardiovascular outcomes, and genetic determinations of hypertension in Chinese
Detailed Description
Blood pressure is a quantitative trait affected by both genetic and environmental factors. Stanford-Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) is an international genetic ...
Eligibility Criteria
Inclusion
- Age of subjects when recruited must be between 35 and 60 years. Subjects over age 60 may also be eligible provided that documentation of their hypertension status prior to age 60 is available.
- Chinese ancestry, i.e. all four grandparents Chinese. Hypertension is defined as follows: systolic BP (SBP) greater than or equal to (\>=) 160 mm Hg or diastolic BP (DBP) \>= 95 mm Hg or taking 2 medications for high blood pressure (Stage II hypertension). Alternatively the subject could have uncontrolled hypertension, i.e. taking 1 medication for high blood pressure and has either systolic BP \>= 140 or diastolic \>= 90 mm Hg.
Exclusion
- One of the affected sibs is adopted (i.e. no parent in common) or if the sibs have only one parent in common.
- Both parents have been treated for hypertension before the age of 60. If offspring reports about their parents' hypertension status are conflicting, then a single reliable report of hypertension in both parents before age 60 is cause for exclusion. This exclusion criterion, however, does not apply to discordant sib-pairs.
- Diabetic individuals were excluded. Diabetes uncovered as a result of SAPPHIRe lab work does not lead to exclusion however.
- Severe kidney disease (except stones and remote infections) of creatinine \> 1.5 mg/dl, unless documented proof that the subject met inclusion criteria prior to increase in creatinine levels.
- A body-mass index greater than 35.
- In addition, the following conditions are considered as cause for exclusion: ongoing (or within the past 6 months) treatment for cancer; terminal illness (life expectancy fewer than 6 months); liver cirrhosis or any other chronic illness; pregnancy or fewer than 6 months post-partum.
Key Trial Info
Start Date :
October 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
1038 Patients enrolled
Trial Details
Trial ID
NCT00631956
Start Date
October 1 2006
End Date
December 1 2016
Last Update
April 7 2016
Active Locations (1)
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1
Division of Biostatistics and Bioinformatics, NHRI
Miaoli County, Taiwan, 350