Status:
COMPLETED
LBH589 in Combination With Capecitabine Plus/Minus (±) Lapatinib in Breast Cancer Patients
Lead Sponsor:
SCRI Development Innovations, LLC
Collaborating Sponsors:
Novartis
Conditions:
Breast Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This single center Phase I dose escalation trial will evaluate the safety, tolerability and efficacy of LBH589 when combined with capecitabine and lapatinib in three parts. Part 1 will determine the m...
Detailed Description
LBH589 will be evaluated when administered twice weekly at the following possible dose levels: 20 mg, 30 mg, 45 mg, and 60 mg. Capecitabine will be paired with LBH589 and will range in dose from 825 m...
Eligibility Criteria
Inclusion
- Histologically documented metastatic or locally unresectable, incurable malignancy for which capecitabine is clinically appropriate.
- Male or female patients aged ≥ 18 years old.
- Maximum of 3 prior regimens in a metastatic setting allowed and may include other targeted agents, immunotherapy and chemotherapy.
- Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) criteria.
- Eastern Cooperative Oncology Group performance status (ECOG PS) 0 or 1.
- Baseline MUGA or ECHO must demonstrate LVEF \> than the lower limits of the institutional normal.
- Laboratory values as follows:
- ANC \> 1500/μL
- Hgb \> 9 g/dL
- Platelets \> 100,000/uL
- Bilirubin \< 1.5 mg/dL
- AST/SGOT \< 2.5 x ULN or \< 5.0 x ULN and ALT/SGPT in patients with liver metastases
- Creatinine \< 1.5 mg/dL or calculated creatinine clearance \> 50 ml/min
- Albumin \> 3 g/dL
- Potassium \> lower limit of normal (LLN)
- Phosphorous \> LLN
- Calcium \> LLN
- Magnesium \> LLN
- Women of childbearing potential must have a negative serum or urine pregnancy test performed within 7 days prior to start of treatment and must commit to begin two acceptable methods of birth control, one highly effective method of birth control and one additional effective method at the same time before starting treatment.
- Life expectancy \> 12 weeks.
- Accessible for treatment and follow-up.
- All patients must be able to understand the nature of the study and give written informed consent prior to study entry.
- Additional Breast Cancer Patient Subset (Part 2 and Part 3)
- Incurable carcinoma of the breast, with measurable locally recurrent or metastatic disease.
- ICH 3+ overexpression or FISH amplification documented by a local laboratory in primary or metastatic tumor tissue.
- Prior treatment with an anthracycline, taxane, and trastuzumab or not a candidate for such treatment. Patient may have received these drugs in combination or in sequence for the treatment of locally advanced or metastatic disease and/or adjuvant therapy.
Exclusion
- Prior treatment with an HDAC inhibitor or current treatment with valproic acid.
- Previous treatment with capecitabine.
- Impaired cardiac function including any of the following:
- Screening ECG with a QTc \> 450 msec.
- Congenital long QT syndrome.
- History of sustained ventricular tachycardia.
- Any history of ventricular fibrillation or torsades de pointes.
- Bradycardia defined as heart rate \< 50 beats per minute. Patients with a pacemaker and heart rate \> 50 beats per minute are eligible.
- Myocardial infarction or unstable angina within 6 months of study entry.
- Congestive heart failure (NY Heart Association class III or IV).
- Right bundle branch block and left anterior hemiblock (bifascicular block).
- Atrial fibrillation or flutter.
- Ongoing therapy with antiarrhythmics or other medications associated with QTc prolongation.
- Uncorrected hypokalemia or hypomagnesaemia.
- Uncontrolled hypertension (systolic blood pressure \[BP\] 180 or diastolic BP \> 100 mm Hg) or uncontrolled cardiac arrhythmias.
- Active CNS disease, including meningeal metastases.
- Known diagnosis of human immunodeficiency virus (HIV) infection.
- Unresolved diarrhea \> CTCAE grade 1.
- Concomitant requirement for medication classified as CYP3A4 inducers or inhibitors.
- Patients with a history of allergic reactions attributed to compounds of similar chemical or biologic composition to lapatinib.
- Patients with known hypersensitivity to 5-fluorouracil chemotherapy, investigational drug therapy, major surgery \< 4 weeks prior to starting study drug or patients that have not recovered from side effects of previous therapy.
- Patient is \< 5 years free of another primary malignancy except if the other primary malignancy is not currently clinically significant or requiring active intervention, or if other primary malignancy is a basal cell skin cancer or a cervical carcinoma in situ. Existence of any other malignant disease is not allowed.
- Concomitant use of any anti-cancer therapy or radiation therapy.
- Pregnant or breast feeding or female of reproductive potential not using two effective methods of birth control.
- Male patients whose sexual partners are women of childbearing potential not using effective birth control.
- Patients with gastrointestinal (GI) tract disease, causing the inability to take oral medication, malabsorption syndrome, a requirement for intravenous (IV) alimentation, prior surgical procedures affecting absorption, uncontrolled inflammatory GI disease (e.g., Crohn's disease, ulcerative colitis).
- Other concurrent severe, uncontrolled infection or intercurrent illness, including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Patients taking any medications listed in "Prohibited Medications" for both capecitabine and lapatinib .
- Patients with uncontrolled coagulopathy (PT and/or PTT \> 1.2 x ULN; patient must also be on stable dose of anticoagulant for a defined medical indication).
- Abnormal thyroid function (TSH or free T4) detected at screening. Patients with known hypothyroidism who are stable on thyroid replacement are eligible.
- Additional Breast Cancer Patient Subset (Part 2 and Part 3)
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00632489
Start Date
May 1 2008
End Date
July 1 2011
Last Update
June 8 2015
Active Locations (1)
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1
Tennessee Oncology, PLLC
Nashville, Tennessee, United States, 37023