Status:
COMPLETED
The Effect of Cycloserine on Smoking Behavior in Nicotine Dependent Smokers
Lead Sponsor:
Yale University
Collaborating Sponsors:
VA Connecticut Healthcare System
Conditions:
Smoking
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
A total of 20 subjects will participate in this four week, between groups, double-blind, placebo controlled study. Subjects will participate in two experimental sessions separated by approximately one...
Eligibility Criteria
Inclusion
- female and male smokers, aged 18 to 55 years;
- history of smoking daily for the past 12 months, at least 10 cigarettes daily;
- CO level \> 10ppm;
- for women: not pregnant as determined by pregnancy screening, nor breast feeding, and using acceptable birth control methods other than OCP;
- Non-treatment seeking nicotine dependent smokers.
Exclusion
- history of heart disease, renal or hepatic diseases or other medical conditions that the physician investigator deems as contraindicated for the patient to be in the study;
- regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics) and/or recent psychiatric diagnosis and treatment for Axis I disorders including major depression, bipolar affective disorder, schizophrenia and panic disorder within the past year;
- current dependence on alcohol or on drugs other than nicotine;
- regular use of any other tobacco products than cigarettes, including smokeless tobacco and nicotine products;
- allergy to cycloserine;
- subjects with epilepsy or a history of seizures;
- Treatment seeking nicotine dependent smokers.
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00633256
Start Date
December 1 2006
End Date
February 1 2008
Last Update
April 11 2012
Active Locations (1)
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1
West Haven VA
West Haven, Connecticut, United States, 06516