Status:
COMPLETED
A Comparison of the Microdose Leuprolide Protocol vs. Luteal Phase Ganirelix Protocol in Women Who Are or Who Are Predicted to be Low Responders
Lead Sponsor:
UConn Health
Conditions:
Infertility
Eligibility:
FEMALE
21-44 years
Brief Summary
Patients who have undergone in vitro fertilization (IVF) and produced four or less follicles or had four or less oocytes (eggs) retrieved are often referred to as poor responders. We will refer to the...
Detailed Description
Women who demonstrate a suboptimal response to controlled ovarian hyperstimulation (COH) are a challenge to treat with assisted reproductive technologies such as in vitro fertilization (IVF). Such pat...
Eligibility Criteria
Inclusion
- Women ages 21-44 undergoing IVF for infertility
- Prior IVF cycle with poor response (≤4 follicles on ultrasound,≤ 4 oocytes retrieved, peak estradiol \<1000 pg/mL, prior IVF cycle cancelled for poor response)
- OR
- Predicted poor response (age \>40, basal FSH ≥10 mIU/mL, prior poor response to gonadotropin (peak estradiol \<500 pg/mL))
Exclusion
- Medical contraindications for oral contraceptive pills, injectable gonadotropin medications, estradiol, or progesterone in oil use.
- Medical contraindications to pregnancy
- Prior IVF cycle with Microdose Protocol or Luteal Phase Ganirelix Protocol
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00633555
Start Date
July 1 2006
End Date
September 1 2010
Last Update
May 25 2018
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