Status:
TERMINATED
A Pilot Study of 18F-FLT in Pediatric Patients With Central Nervous System (CNS) Tumors
Lead Sponsor:
Dana-Farber Cancer Institute
Collaborating Sponsors:
Boston Children's Hospital
Conditions:
Tumors of the Central Nervous System
Eligibility:
All Genders
Up to 21 years
Phase:
PHASE1
Brief Summary
In spite of numerous advances in neuroimaging techniques, the diagnosis of pediatric brain tumors relies on the pathologic evaluation of material obtained at the time of the initial operation. While 1...
Detailed Description
Patients will undergo standard pre-diagnostic imaging of the sites of disease using standard MRI techniques. If disease is suspected in both the brain and spine, then both imaging modalities should be...
Eligibility Criteria
Inclusion
- Pediatric patients with newly diagnosed central nervous system tumors undergoing planned surgical resection within 21 days.
- Patients should be \< 21 years of age at the time of diagnosis.
- Patients should be capable of achieving imaging without the need for sedation or anesthesia.
- Karnofsky Performance Status ≥ 50. For infants, the Lansky play scale ≥ 50% can be substituted.
- Patients must not be pregnant or nursing.
- Signed Informed Consent.
- Patients receiving steroids and/or anti-seizure medications are eligible for this study.
Exclusion
- Prior radiation therapy and/or chemotherapy are not permitted.
- Active infection
- Pregnancy or breast feeding
- Serious concurrent medical illness
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00633958
Start Date
March 1 2008
End Date
March 1 2010
Last Update
October 20 2021
Active Locations (1)
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1
Children's Hospital Boston
Boston, Massachusetts, United States, 02115