Status:
TERMINATED
Biomarkers in Exhaled Breath From Asthmatic Patients
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Asthma
Eligibility:
All Genders
18-75 years
Brief Summary
This study will look for a relationship between asthma and factors released from the lungs in exhaled breath. If a relationship can be established, the identified factors may be used as biomarkers to ...
Detailed Description
Asthma is a major public health problem that is associated with significant morbidity and mortality. Patients at increased risk for asthma decompensations include those with severe asthma that is refr...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA - ASTHMA:
- Patients will be between 18 and 75 years of age, male or female, with a diagnosis of asthma for at least one year.
- Oxygen saturation on room air greater than or equal to 92 percent.
- EXCLUSION CRITERIA - ASTHMA:
- Diagnosis of a pulmonary disorder other than asthma (for example: chronic bronchitis, emphysema, cystic fibrosis, bronchiectasis, sarcoidosis, HIV-related lymphocytic airway inflammation).
- Cigarette smoking within the past 3 months or a prior history of greater than 10 cumulative pack-years.
- History of coronary artery disease.
- INCLUSION CRITERIA HEALTHY VOLUNTEERS:
- Research volunteers will be between 18 and 75 years of age, male or female.
- Oxygen saturation on room air greater than or equal to 92 percent.
- EXCLUSION CRITERIA HEALTHY VOLUNTEERS:
- Same as the asthmatic exclusion criteria plus a history of asthma.
- Reversible Airflow Obstruction (increase in FEV (1) by 12 percent and 200 cc after inhaled beta 2-agonist)
Exclusion
Key Trial Info
Start Date :
February 29 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 28 2012
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00635271
Start Date
February 29 2008
End Date
November 28 2012
Last Update
December 5 2019
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892