Status:
UNKNOWN
Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
Pfizer
Conditions:
Atherosclerosis
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
Atherosclerosis is a disease in which the blood vessels become blocked by plaques (consisting of fat, calcification, and fibrous tissue), reducing blood flow to vital organs and tissues.Blockage of th...
Detailed Description
Candidates for bilateral carotid endarterectomy (CEA) who meet study criteria will provide informed consent before their randomization. Before the first CEA, the patient will have MRI, US, and EBCT ex...
Eligibility Criteria
Inclusion
- Men or women
- \>18 yrs old
- Expected to have an endarterectomy on each carotid artery
- No contraindications for atorvastatin
- Stable cardiovascular health
- Lipid lowering treatment less than 6 mo duration
- Diabetic included if diabetes is controlled
- Patient is not claustrophobic
- Patient has evaluable carotid plaques.
Exclusion
- Patient has had previous carotid endarterectomy,stenting, or other procedure
- Unstable cardiovascular status
- Hypersensitivity to statin therapy
- Neck anatomy preventing acquiring bilateral evaluable plaques
- Weight over 285 lbs.
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2010
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00640744
Start Date
February 1 2006
End Date
February 1 2010
Last Update
December 7 2010
Active Locations (1)
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1
Baylor College of Medicine
Houston, Texas, United States, 77030