Status:
COMPLETED
Methionine-Restriction Diet (MRD) in Obese Adults With Metabolic Syndrome
Lead Sponsor:
Pennington Biomedical Research Center
Collaborating Sponsors:
Orentreich Foundation for the Advancement of Science, Inc.
Conditions:
Metabolic Syndrome
Eligibility:
All Genders
21-60 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine if limiting dietary methionine (MET), one of the 10 essential amino acids (which make up proteins), causes weight loss and/or improves glucose metabolism.
Detailed Description
Methionine deficient diets have been shown to increase metabolic rate, decrease weight and extend lifespan in rodents. A methionine deficient diet has been tested for 17 weeks in humans without advers...
Eligibility Criteria
Inclusion
- Male or female between the ages of 21 to 60, inclusive
- Waist greater than 40 inches for men and 35 inches for women
- Weight has been stable for at least 6 months (no more than 5 pounds gained or lost)
- For women of childbearing potential: subject must be willing to use acceptable form of contraception (pill, condom, diaphragm etc.)
- At least 2 of the following:
- HDL cholesterol
- Men \< 40 mg/dL
- Women \< 50 mg/dL Triglycerides ≥150 mg/dL Blood pressure ≥130/≥ 85 mmHg Fasting glucose ≥110-125 mg/dL
Exclusion
- Type 1 or Type 2 diabetes
- History of heart attack or stroke
- Pregnant or breastfeeding or planning to become pregnant during the study
- Cancer (other than non-melanoma skin) within the last 5 years
- Significant illness requiring medication
- Inability to read and follow directions in English
- Donated blood in the last 2 months.
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2008
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT00640757
Start Date
July 1 2006
End Date
December 1 2008
Last Update
December 18 2015
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