Status:
COMPLETED
A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer.
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This 2 arm study will assess the efficacy and safety of Avastin in combination with irinotecan + 5-fluorouracil/folinic acid, versus irinotecan + fluorouracil/folinic acid alone, as first line treatme...
Eligibility Criteria
Inclusion
- adult patients, \>=18 years of age;
- histologically confirmed adenocarcinoma of the colon or rectum, with metastatic disease;
- \>=1 measurable lesion;
- ECOG performance status of \<=1.
Exclusion
- prior systemic therapy for advanced or metastatic disease;
- adjuvant or neo-adjuvant treatment for non-metastatic disease in past 6 months;
- other malignancy within past 5 years, except cured basal cell cancer of skin or cured cancer in situ of cervix;
- clinically significant cardiovascular disease in past 6 months.
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
214 Patients enrolled
Trial Details
Trial ID
NCT00642577
Start Date
July 1 2007
End Date
December 1 2010
Last Update
December 22 2022
Active Locations (12)
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1
Beijing, China, 100021
2
Beijing, China, 100036
3
Beijing, China, 100071
4
Chongqing, China, 400042