Status:
COMPLETED
Comparative Study of 5 Days of M02-472 Clarithromycin Extended-Release Tablets to 7 Days of Clarithromycin Immediate-Release Tablets for the Treatment of Exacerbation of Chronic Bronchitis
Lead Sponsor:
Abbott
Conditions:
Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB).
Eligibility:
All Genders
40+ years
Phase:
PHASE3
Brief Summary
To compare the efficacy of a 5-day course of clarithromycin extended-release tablets (2 x 500 mg QD) with that of a 7-day course of clarithromycin immediate-release tablets (1 x 500 mg BID) in the tre...
Eligibility Criteria
Inclusion
- Ambulatory subject who does not require intravenous antibiotic therapy.
- Subject who has a medical history of chronic bronchitis.
- A history of regular medication use (\>=3 consecutive months within the past 2 years) to treat pulmonary disease.
- Subject must have evidence of pulmonary function test abnormalities.
- The onset of signs and symptoms of the current exacerbation must occur within 14 days before Evaluation 1.
Exclusion
- Medical history of hypersensitivity, allergic or adverse reactions to clarithromycin, erythromycin, or any of the macrolide antibiotics.
- A female who is pregnant or is lactating.
- Subject who has suspected or known (positive chest radiograph) pneumonia.
- Subject who has evidence of significant bronchiectasis (by CT) or atelectasis, active tuberculosis or other mycobacterial infection, bullous emphysema, pulmonary embolism, lung abscess, tumor (primary or metastatic) involving the lung, pleural effusion, or cystic fibrosis that could confound the assessment of signs and symptoms of ABECB.
- Subject who requires parenteral antibiotic therapy.
- Subject who requires hospitalization for treatment of current episode of ABECB.
- Subject who has any other infection or condition, which necessitates use of a concomitant systemic antibiotic.
- Subject who has any underlying condition/disease, which would be likely to interfere with the completion of the course or absorption of study drug therapy or follow-up.
- Subject who has a severe or complicated lower respiratory tract infection or a severely compromised respiratory status (i.e., oxygen dependent, requiring hospitalization).
- Known significant renal or hepatic impairment.
Key Trial Info
Start Date :
December 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
465 Patients enrolled
Trial Details
Trial ID
NCT00645086
Start Date
December 1 2002
Last Update
March 27 2008
Active Locations (146)
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1
Birmingham, Alabama, United States, 35235
2
Birmingham, Alabama, United States, 35242
3
Columbiana, Alabama, United States, 35051
4
Hoover, Alabama, United States, 35216