Status:
TERMINATED
Pilot Study of dMRI as a Tool for Early Evaluation of Tumor Response in Diffuse Large B-cell Lymphoma
Lead Sponsor:
University of Michigan Rogel Cancer Center
Conditions:
Diffuse Large B Cell Lymphoma
Eligibility:
All Genders
18+ years
Brief Summary
This research study is designed to test whether the results of a diffusion MRI scan performed after one cycle of chemotherapy for lymphoma can accurately predict the outcome of treatment for individua...
Detailed Description
Different types of functional imaging are under investigation as a tool to predict response to treatment, as imaging soon after starting therapy might be able to better define the likelihood of respon...
Eligibility Criteria
Inclusion
- Patients with a new diagnosis of CD20 Positive diffuse large B cell lymphoma (LBCL) of any stage, including subtypes mediastinal large B cell, centroblastic, immunoblastic, T cell rich B cell and anaplastic B cell lymphoma, who will receive standard R/CHOP as first line chemotherapy will be included.
- Patients must be age 18 or older.
- No selection will be made on the basis of gender, race or ethnicity.
Exclusion
- Patients will be excluded if the diagnosis of diffuse large B cell lymphoma cannot be confirmed.
- Patients receiving treatment other than R/CHOP or R/CHOP followed by radiotherapy or who have previously been treated for DLBCL will be excluded. - Patients with HIV infection will also be excluded. No selection will be made based on other medical problems or laboratory values, except as they affect the patient's eligibility to receive standard R/CHOP chemotherapy as determined by the treating physician.
- Patients who have magnetic metal implants or fragments in their body that are incompatible with MRI will be excluded.
Key Trial Info
Start Date :
November 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00645359
Start Date
November 1 2006
End Date
April 1 2014
Last Update
April 14 2017
Active Locations (1)
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1
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109