Status:
UNKNOWN
Genetic Expression in Schizophrenics Treated With SSRI Augmentation: Relationship to Clinical and Cognitive Function
Lead Sponsor:
Sha'ar Menashe Mental Health Center
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
In our study we aim to examine the effect of SSRI augmentation on negative symptoms and cognitive function in schizophrenia patients as well as to examine the effect of SSRI augmentation on the RNA an...
Detailed Description
Clinical studies have shown that adding selective serotonin reuptake inhibitor (SSRI) antidepressants to antipsychotics can improve negative symptoms of schizophrenia in patients unresponsive to antip...
Eligibility Criteria
Inclusion
- Age 18-65
- A diagnosis of schizophrenia (DSM-IVTR)
- Antipsychotic dose unchanged for at least 2 weeks prior to study
- SANS score\>= 3 on at least one of the global measures of affective blunting, alogia or avolition.
- Knowledge of Hebrew
Exclusion
- Dementia or other serious neurological disorders
- History of alcohol or drug use
- Patients with a legal guardian
- Patients involuntarily hospitalized by order of the district psychiatrist
- Use of antidepressants within 1 month of the study
- Renal or hepatic disorder
- Patients with upper GI bleeds
- Patients with SIADH syndrome
- Pregnant woman
- Criteria for the cessation of the study after initial commencement:
- Severe adverse events (including but not only GI, cardiovascular, neurologic, hematologic or urologic severe adverse events)
- Emergent suicidality
- Emergence of hypomanic or manic symptoms
- If the subject requests to stop
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2009
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00645580
Start Date
April 1 2008
End Date
April 1 2009
Last Update
February 19 2009
Active Locations (1)
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1
Sha'ar Menashe Mental Health Center
Mobile Post Hefer, Israel, 37806