Status:
WITHDRAWN
Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Viral Pneumonia
Bacterial Pneumonia
Eligibility:
All Genders
Up to 18 years
Brief Summary
The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose that the lev...
Detailed Description
Most often, viruses are the cause of pneumonia in children. However, viral pneumonias are frequently associated with secondary bacterial pneumonia. It is important, though difficult, to differentiate ...
Eligibility Criteria
Inclusion
- Children from birth to 18 years intubated for respiratory failure or for surgery as mentioned above within 48 hours of intubation.
Exclusion
- Use of antibiotics \>72 hours preceding the study (not applicable to the definite bacterial pneumonia group)
- Use of oral/parenteral glucocorticoid therapy \<2 weeks prior to admission
- Presence of tracheostomy
- Active treatment for pulmonary arterial hypertension
- Mechanical ventilation with FIO2 \>0.6, MAP\>20
- Presence of severe pulmonary interstitial emphysema, pneumothorax, bradycardia (heart rate, \<80 beats/min in neonates, \<70 beats/min in infants), hypotension (mean arterial pressure, \<40 mm Hg in neonates, \<50 mm Hg in infants), and platelet count of \<30,000/mm3.
- Immunodeficient or immunocompromised due to other conditions.
- Enrollment in another interventional study that employs BAL.
Key Trial Info
Start Date :
March 24 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 26 2008
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00645619
Start Date
March 24 2008
End Date
March 26 2008
Last Update
December 26 2018
Active Locations (1)
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1
Childrens Medical Center
Dallas, Texas, United States, 75235