Status:
UNKNOWN
Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Aortic Valve Stenosis
Eligibility:
All Genders
18+ years
Brief Summary
Pathophysiology of Aortic Valve Stenosis remains poorly known. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design.
Detailed Description
Aortic valve stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS has long been considered as a passive and degenerative...
Eligibility Criteria
Inclusion
- Patients:
- Inclusion criteria :
- Age \>=18 years
- Pure isolated degenerative aortic valve stenosis
- Exclusion criteria :
- Rheumatic, congenital or post-radiation aortic stenosis
- Severe renal insufficiency (clearance \< 30 ml/min)
- Aortic insufficiency \> or = grade 2/4
- Other valve disease \> or = grade 2/4
- Controls
- Inclusion criteria :
- \- Age \>=18 years
- Exclusion criteria :
- Known first degree relative with aortic valve stenosis
- Severe renal insufficiency (clearance \< 30 ml/min)
- Any valve disease \> or = grade 2/4
Exclusion
Key Trial Info
Start Date :
March 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2017
Estimated Enrollment :
2200 Patients enrolled
Trial Details
Trial ID
NCT00647088
Start Date
March 1 2008
End Date
December 1 2017
Last Update
March 1 2017
Active Locations (1)
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1
Assistance Publique - Hôpitaux de Paris, Bichat Hospital
Paris, France, 75018