Status:
TERMINATED
Clinical Evaluation of 18F-DOPA Positron Emission Tomography in Medullary Thyroid Cancer
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Thyroid Neoplasm
Thyroid Carcinoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Medullary thyroid carcinoma (MTC) is a rare tumor arising from C cells of the thyroid gland and belonging to the endocrine tumors. 18F-DOPA PET, based on tha capacity of endocrine tumor cells to take-...
Detailed Description
In patients MTC and persistently elevated calcitonin levels, the challenge is finding the site of residual disease. Since the only satisfying treatment is surgery, the early detection and precise loca...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients up to 18 years old with medullary thyroid cancer / carcinoma
- Patients with medullary thyroid cancer / carcinoma recurrence, which have a high calcitonin level / rate, more than 100pg/ml, associated - or not - to a high CEA (Carcinoembryonic Antibodies) level / rate, dated from less than 3 months
- Patients with a less than 3 months conventional imaging checkup (cervical ultrasonography, cervical-chest-abdomen tomography and / or magnetic resonance imaging, abdomen ultrasonography, osseous / bones radionuclide imaging), in which the tumor site not certainty located
- Informed Consent Form signed and dated by patients
- Patients which are "SECURITE SOCIALE" affiliated
- Exclusion criteria:
- Pregnant or suckling women
- Women able to procreate, without efficient birth control
- Patients already included in another Nuclear Medicine or Imaging research protocol using ionizing radiations; the efficient dose accumulation will not exceed 20 mSv.
Exclusion
Key Trial Info
Start Date :
August 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00647140
Start Date
August 1 2007
End Date
February 1 2010
Last Update
July 7 2010
Active Locations (1)
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1
Hôpital Antoine Beclere
Clamart, France, 92140