Status:
COMPLETED
Effect of Glucose Control on the Response to Aspirin in Type 2 Diabetic Patients
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Diabetes Mellitus, Type II
Eligibility:
All Genders
Brief Summary
The efficacy of low dose aspirin appears to be substantially lower in diabetic patients, compared to patients without diabetes. We will perform an observational study where we follow up patients with...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Type 2 DM.
- Patients that take aspirin.
- Antecubital forearm veins allowing technically good sampling for platelet studies.
- Reduced Laboratory response to aspirin.
- HbA1c \> 8 %
- The physician decides that there is an indication for glucose control.
- Exclusion Criteria:
- Acute ischemic stroke, acute coronary syndrome, (myocardial infarction or unstable angina pectoris), or revascularization by PCI or by-pass surgery within the last 6 months.
- Acute kidney disease or chronic kidney disease with creatinine clearance \<30.
- Acute liver disease or chronic liver disease with severe liver impairment.
- Need for treatment with anticoagulants, clopidogrel, NSAID's, or thiazolidinediones.
- Thrombocytopenia (platelet count \<150 x 109/L)
Exclusion
Key Trial Info
Start Date :
November 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00649909
Start Date
November 1 2008
End Date
November 1 2010
Last Update
August 10 2017
Active Locations (1)
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1
Hadassah Medical Organization
Jerusalem, Israel