Status:
TERMINATED
Thorax Enlarging Surgery: a Novel Surgical Approach to Emphysema
Lead Sponsor:
KU Leuven
Conditions:
COPD
Emphysema
Eligibility:
All Genders
50-70 years
Phase:
NA
Brief Summary
There is a growing population of end-stage COPD patients for whom surgical treatments like lung transplantation and lung volume reduction surgery are not possible. In such patients, size mismatch betw...
Detailed Description
Lung volume reduction surgery primarily increases vital capacity by reducing RV more than TLC. As the chest wall is the major TLC limiting factor, an alternative approach that could circumvent size mi...
Eligibility Criteria
Inclusion
- patients with end-stage emphysema and
- Disabling dyspnea
- GOLD III or IV
- Residual volume \> 200% predicted
- Total Lung capacity \> 120% predicted
- RV/TLC \> 0.6
- Resting CO2 \< 50 mmHg
- diffusion capacity \> 20% predicted
- age \< 70 years
Exclusion
- previous sternotomy
- contraindication of general anesthesia
- chronic treatment with corticosteroids
- any tobacco use within 6 months
- candidates for lung volume reduction surgery or lung transplantation
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT00650559
Start Date
June 1 2004
End Date
December 1 2006
Last Update
April 1 2008
Active Locations (1)
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1
University hospital Leuven
Leuven, Flanders, Belgium, 3000