Status:
COMPLETED
Water Immersion in Right-Sided Heart Failure: A Pilot Study
Lead Sponsor:
University of Maryland, Baltimore
Conditions:
Right Sided Cardiac Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is an unblinded pilot study comparing (against a randomized control day without water immersion) the diuretic and natriuretic effects of water immersion in patients with right heart failure.
Detailed Description
Patients will be immersed in a tub for 3 hours (on one day) and neurohormones will be obtained before and after immersion. Urine will be collected for quantification and evaluation of sodium concentra...
Eligibility Criteria
Inclusion
- Patients must have right sided failure secondary to right ventricular dysfunction, pulmonary hypertension, or tricuspid regurgitation
- Age greater than 18 years of age
- Right heart catheterization within the last year to rule out left-sided failure.
- Evidence of fluid overload as indicated by 2 or more of the following: 1.) 2+ or more pitting edema of the lower extremities, 2.) scrotal or penile edema, 3.) JVP greater than or equal to 10 cm, 4.) abdominal ascites
Exclusion
- Pulmonary capillary wedge pressure above 16 mmHg or history of elevated left ventricular filling pressures.
- Serum creatinine \> 2.0
- Current use of an angiotensin I converting enzyme inhibitor or angiotensin receptor blocker will preclude participation in the RAS neurohormone portion of the study.
Key Trial Info
Start Date :
December 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT00654264
Start Date
December 1 2007
End Date
December 1 2009
Last Update
March 9 2022
Active Locations (1)
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1
University of Maryland
Baltimore, Maryland, United States, 21201