Status:
UNKNOWN
Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis
Lead Sponsor:
Zhejiang University
Conditions:
Endometriosis
Eligibility:
FEMALE
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to identify the recurrent rate and pregnancy rate of advanced endometriosis after laparoscopic surgery plus GnRHa goserelin acetate treatment.
Detailed Description
In order to decrease endometriosis recurrence and enhance pregnancy rate after surgical therapy, it has been proposed to use a post-surgical gonadotropin-releasing-hormone agonist (GnRHa) treatment. D...
Eligibility Criteria
Inclusion
- Age \>=18 years old
- Normal menstruation for 3 months before enrollment (25-35 days）
- Advanced endometriosis confirmed histologically (r-AFS score III-IV) with laparoscopy or laparotomy-pelvic pain and/or dysmenorrhea and/or dyspareunia
- Agreement on the strict follow-up plan
- Without previous hormonal treatment
- Using nonhormonal method of contraception during this study
Exclusion
- Serious heart diseases/pulmonary/liver/kidney diseases
- Previous non-endometriosis relevant surgery possibly influence to abdominal or pelvic pain
- Suspected malignancy in endometriosis
- Coagulation disorders with hemorrhagic tendency
- Pregnancy or lactation
- Allergy to GnRHa
- Previous ineffective treatment with GnRHa
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2010
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00654524
Start Date
March 1 2008
End Date
December 1 2010
Last Update
March 15 2011
Active Locations (1)
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1
Women's Hospital School Of Medicine Zhejiang University
Hangzhou, Zhejiang, China, 310006