Status:
COMPLETED
The Effect of Prometheus (R) Liver Support Dialysis on Cerebral Metabolism in Acute Liver Failure
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Acute Liver Failure
Hepatic Encephalopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The main objective of this study is to investigate the effect of Prometheus liver support dialysis on intracranial pressure, cerebral metabolism and circulation in patients with acute liver failure.
Detailed Description
Acute liver failure (ALF) is a highly mortal medical condition often complicated by multiorgan failure. Apart from severe coagulopathy ALF is characterized by onset of hepatic encephalopathy and in ma...
Eligibility Criteria
Inclusion
- acute liver failure
- and grade II-IV encephalopathy
- and persistent raised arterial ammonia-concentration above 150 micromol/L
- and informed consent from closest relative and general practitioner
Exclusion
- withdrawal of informed consent
- severe untreated infection
- active bleeding within 48 hours
- suspicion of malignant liver disease
- severe heart insufficiency or middle artery pressure below 60 mmHg in spite of vasoactive therapy
- pregnant or lactating women
- disseminated intravascular coagulation
- clinical suspicion of cerebral damage
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00655304
Start Date
March 1 2007
End Date
June 1 2011
Last Update
July 27 2011
Active Locations (1)
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1
The liverfailure unit, Department of hepatology, Rigshospitalet
Copenhagen, Denmark, 2100