Status:
COMPLETED
Modulation of Lung Injury Complicating Lung Resection
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Royal College of Physicians
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Acute Lung Injury
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether N-acetylcysteine given intravenously 1 day pre-operatively is effective in preventing inflammation in the lungs, as measured by tests on blood, breath...
Detailed Description
Acute lung injury occurs following lung resection in about 5% cases, and has a high mortality of around 50%. Management of these patients is largely supportive. Even in patients who do not develop cli...
Eligibility Criteria
Inclusion
- Elective lung resection for cancer
Exclusion
- Age less than 18 years
- Women of child-bearing age or potential
- Known allergy to N-acetylcysteine
- Oral steroid in the preceding 1 month
- N-acetylcysteine in the preceding 1 month
- Unable to receive standardised anaesthetic approach
Key Trial Info
Start Date :
August 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT00655928
Start Date
August 1 2007
End Date
July 1 2009
Last Update
February 5 2020
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6NP