Status:
UNKNOWN
Looking For Genetic and Environmental Risk Factors and Therapeutic Aspects in Cervical Artery Dissections
Lead Sponsor:
Cervical Artery Dissections and Ischemic Stroke Patients - Consortium
Conditions:
Cervical Artery Dissection
Stroke
Eligibility:
All Genders
18+ years
Brief Summary
The main purpose of this study is to look for genetic and environmental risk factors of cervical artery dissections, a major cause of ischemic stroke in young adults, in a large multicenter case-contr...
Detailed Description
Background: Cervical artery dissections (CAD) are a major cause of ischemic stroke, longstanding disability, and occasionally death in young adults. Several lines of evidence suggest genetic predispos...
Eligibility Criteria
Inclusion
- GROUP1:
- Typical radiological aspect of dissection\* in a cervical artery (carotid and/or vertebral);\* Mural hematoma, pseudoaneurysm, long tapering stenosis, intimal flap, double lumen, or occlusion \> 2 cm above the carotid bifurcation revealing a pseudo aneurysm or a long tapering stenosis after recanalisation
- Written informed consent
Exclusion
- Purely intracranial dissection
- Dissection occurring after an endovascular procedure
- Known mendelian genetic disorder that can explain the dissection (e.g. vascular Ehlers-Danlos syndrome)
- GROUP2:
- Inclusion Criteria:
- Recent ischemic stroke
- No signs of CAD on extracranial duplex sonography and angiography (digital subtraction or magnetic resonance or CT), performed \< 7 days after the stroke
- Written informed consent
Key Trial Info
Start Date :
July 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
4169 Patients enrolled
Trial Details
Trial ID
NCT00657969
Start Date
July 1 2005
End Date
September 1 2009
Last Update
October 21 2009
Active Locations (24)
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1
Sanatorio Allende
Córdoba, Argentina, 5000
2
Department of Neurology, University Hospital of Brussels (ULB)
Brussels, Belgium, 1070
3
Department of Neurology, University Hospital of Leuven
Leuven, Belgium, 3000
4
Department of Neurology, Helsinki University Central Hospital
Helsinki, Finland, 00290