Status:
UNKNOWN
Mesenchymal Stem Cell Transplantation in the Treatment of Chronic Allograft Nephropathy
Lead Sponsor:
Fuzhou General Hospital
Conditions:
Kidney Transplant
Chronic Allograft Nephropathy
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
PHASE2
Brief Summary
Mesenchymal Stem Cell (MSC) have been shown to have immunosuppressive and repairing properties. the investigators will infuse expanded MSC into patients who develop Chronic Allograft Nephropathy. The ...
Detailed Description
Kidney transplantation is a common procedure in hospitals, but organ rejection and chronic nephrotoxicity are potential problems for the patient. Approximately ninety percent of the protocol biopsies ...
Eligibility Criteria
Inclusion
- Recipients of a renal allograft, Male and female patients age 18 to 60 years of age.
- Ability to provide written informed consent.
- The serum creatinine form 176umol/L(2mg/ml) to 440umol/L(5mg/ml)
- Renal biopsy Criteria: chronic allograft nephropathy (Banff I-II).
- Immunosuppressant:CNI and MMF and Sirolimus
- Written informed consent, compliant with local regulations.
Exclusion
- Recipients with leucopenia (WBC \< 3000/mm³), thrombocytopenia (Thr \< 100.000/mm³),or hyperlipidemia (Tot Chol \> 300 mg/dl or Triglycerides \> 300 mg/dl).
- Recipients of multiple organs.
- Pregnant women.
- Previous history of malignancy
- Active infection including hepatitis B, hepatitis C, HIV, or TB as determined by a positive skin test or clinical presentation, or under treatment for suspected TB.
- Evidence of cardiovascular disease, existing congestive cardiac failure on physical exam and/or acute coronary syndrome in past 6 months.
- Inadequate compliance to treatment.
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00659620
Start Date
May 1 2008
End Date
May 1 2010
Last Update
April 16 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Fuzhou General Hospital
Fuzhou, Fujian, China, 350025