Status:
COMPLETED
Is Pentoxifylline Able to Improve Olfactory Sensitivity?
Lead Sponsor:
Technische Universität Dresden
Conditions:
Olfaction Disorders
Eligibility:
All Genders
18-50 years
Brief Summary
Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentox...
Detailed Description
Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) c...
Eligibility Criteria
Inclusion
- hyposmic or functionally anosmic patients TDI-score \<31
- age: 18-50 years
- odor threshold: better than 1
- cause of smell loss: post traumatic, postinflammatory, idiopathic
Exclusion
- normosmic patients,
- patients with contraindications for application of pentoxifylline
- patients that cannot give written agreement to the study
- patients under 18 years and over 50 years of age
Key Trial Info
Start Date :
November 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2016
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00660868
Start Date
November 1 2009
End Date
January 1 2016
Last Update
February 5 2016
Active Locations (1)
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1
Zentrum für Riechen und Schmecken, Universitäts- HNO- Klinik Dresden
Dresden, Germany, 01307