Status:
WITHDRAWN
Inhaled Corticosteroids on Airway Smooth Muscle in Asthma
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
Conditions:
Asthma
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
The main objective is to evaluate how treatment with inhaled corticosteroids (ICS) affects the characteristics of airway smooth muscle (ASM) cells from asthmatic subjects. Our hypothesis is that airwa...
Detailed Description
Aims and Objectives Most of the work published to date on the effect of steroids on ASM has been carried out in animal models or in in vitro experiments. We would like to evaluate in vivo whether abn...
Eligibility Criteria
Inclusion
- Physician diagnosis of asthma
- Age 18-60
- Intermittent asthma symptoms \< once/week
- FEV1\>80% of predicted
- Not on inhaled corticosteroid therapy
Exclusion
- Previous long-term use of inhaled corticosteroids (within 1 year of entry into study)
- Past history of hypersensitivity to budesonide
- Current smokers, or less than 3 years since quitting smoking
- Less than 4 weeks from an exacerbation
- On steroid-sparing agent or immunosuppressant such as azathioprine, methotrexate and ciclosporin
- Concomitant anti-IgE therapy
- Pregnancy
- Previous bronchoscopy within three months of this study
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00661973
Start Date
April 1 2008
End Date
March 1 2011
Last Update
September 13 2019
Active Locations (1)
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1
Asthma lab, Royal Brompton Hospital, Sydney Street
London, United Kingdom, SW3 6NP